METABOLIC MODULATION OF GLIOBLASTOMA WITH DICHLOROACETATE PDF

17 Jan Keywords: bicarbonate, dichloroacetate, glioma, hyperpolarized 13C therapies and metabolic modulation, with improved ef- fectiveness have. Metabolic Modulation of Glioblastoma with Dichloroacetate (DCA) can reverse this cancer-specific metabolic and mitochondrial remodeling in glioblastoma. Metabolic modulation of glioblastoma with dichloroacetate. Authors: ED. Michelakis, G Sutendra, P Dromparis, L. C. Webster, A Haromy, E Niven, C. Maguire.

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Cancer Chemother Pharmacol ; Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer.

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology Gopinath SutendraEvangelos D Michelakis Front.

Pharmacokinetics and pharmacodynamics of dichloroacetate in children with lactic acidosis due to severe malaria. Dichloroacetate DCA as a potential metabolic-targeting therapy for cancer. Log in through your institution Log in via OpenAthens. Pyruvate Dehydrogenase Kinases in the Nervous System: We tested whether the small-molecule and orphan drug dichloroacetate DCA can reverse this cancer-specific metabolic and mitochondrial remodeling in glioblastoma.

Metabolic Modulation of Glioblastoma with Dichloroacetate

Based on this phase I trial an effect of DCA in the treatment of advanced and treatment refractory solid tumors can neither be supported nor negated References Publications referenced by this paper. The latest chapter in the seemingly never-ending saga of dichloroacetate as a cancer treatmenthttps: Agbenyega T, et al.

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DCA depolarized mitochondria, increased mitochondrial reactive oxygen species, and induced apoptosis in GBM cells, as well as in putative GBM stem cells, both in vitro and in vivo. J Cancer Res Clin Oncol ; Understanding the Warburg effect: Metabolic modulation of cancer: The best tumor responses reported were stable diseases in eight patients. Generate a o for use with external citation management software.

Hexokinase-2 bound to mitochondria: Invest New Drugs ; Dichloroacetate causes reversible demyelination in vitro: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail.

J Palliat Med ; Non-Hodgkin’s Lymphoma Reversal with Dichloroacetate. Please log in to add an alert for this article. Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme, develop resistance to cell death, in part as a result of a switch from mitochondrial oxidative phosphorylation to cytoplasmic glycolysis.

Metabolic modulation of glioblastoma with dichloroacetate. – PubMed – NCBI

Bachoo Cell metabolism Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme, develop resistance to cell death, in part as a result of a switch from mitochondrial oxidative phosphorylation to cytoplasmic glycolysis. Association of reactive oxygen species levels and radioresistance in cancer stem cells Maximilian DiehnRobert W.

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Freshly isolated glioblastomas from 49 patients woth mitochondrial hyperpolarization, which was rapidly reversed by DCA.

Medullary thyroid carcinoma relapse reversed with dichloroacetate: Metabolic Modulation of Glioblastoma with Dichloroacetate. Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer Metabolci B.

Abstract Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme, develop resistance to cell death, in part as a result of a switch from mitochondrial oxidative phosphorylation to cytoplasmic glycolysis. Add to My Bibliography. Metabolic modulation of glioblastoma with dichloroacetate.

Case reports Strum et al. You are currently viewing the abstract.